Work

The 5′ Untranslated Region of the Capsid Protein 2 Gene of Mink Enteritis Virus Is Essential for Its Expression

Year: 2018

Type: article

Abstract: MEV, a parvovirus, causes acute enteritis in mink. In the present report, we describe an untranslated sequence-dependent mechanism by which MEV regulates capsid gene expression. Our results highlight the roles of untranslated sequences in regulating the transcriptional activity of P38 promoter and translation of capsid genes. These data also reveal the possibility of an unusual translation mechanism in capsid protein expression and the multiple functions of nonstructural protein. A better understanding of the gene expression regulation mechanism of this virus will help in the design of new vaccines and targets for antiviral agents against MEV.

Source: Journal of Virology

DOI: 10.1128/jvi.00787-18

Authors: Shuang-Shuang Yang, Jigui Wang, Zhaoda Li, Shangjin Cui, Weiquan Liu

Institutions: China Agricultural University, Chinese Academy of Agricultural Sciences, Institute of Animal Sciences

Language: English

Topic: Animal Virus Infections Studies

Subfield: Animal Science and Zoology

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: bronze

Funder: Ministry of Science and Technology of the People's Republic of China

Awards: G3579478362, G8104675101