Work

One-pot sequential multi-component reaction: Synthesis of 3-substituted indoles

Year: 2018

Type: article

Abstract: Here, we have developed a 3-component one-pot sequential approach to 3-substituted indoles. The main advantages of this process are step economy, reduced waste, and operational simplicity. The method involves in situ generation of 3-indolylalcohols from the reaction of indoles and aldehydes in the presence of base. Further, nucleophilic substitution of 3-indolylalcohols with various nucleophiles affords 3-substituted indole derivatives. The reaction does not requires any hazardous and expensive metal catalyst. In addition, the reaction is carried out in (1:1) ethanol–water which is considered as environmentally benign solvent. On the other hand, nonsequential 3-component reaction results in the formation of unwanted bisindolylmethanes.

Source: Synthetic Communications

DOI: 10.1080/00397911.2018.1482352

Authors: Paran J. Borpatra, Bhaskar Deka, Basanta K. Rajbongshi, Mohit L. Deb, Pranjal K. Baruah

Institutions: Gauhati University, Cotton University

Language: English

Topic: Synthesis of Indole Derivatives

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: green

Funders: Gauhati University, Science and Engineering Research Board, National Chemical Laboratory