Plant pathogen effector utilizes host susceptibility factor NRL1 to degrade the immune regulator SWAP70
Year: 2018
Type: article
Abstract: Significance Plant pathogens, such as the infamous potato blight agent Phytophthora infestans , deliver effectors inside living plant cells to promote disease. Recent evidence suggests that some effectors will associate with endogenous negative regulators of immunity, or so-called susceptibility (S) factors, inside living plant cells. To date, little is known about how effectors exploit S factors to inactivate the immune system. We discovered that P. infestans effector Pi02860 uses the potato StNRL1 protein as an S factor by promoting its ability to target a positive regulator of immunity, StSWAP70, for proteasome-mediated degradation. Our results reveal that protecting StSWAP70 from degradation by reducing the activity or availability of NRL1 provides a means to attenuate late blight disease.
Language: English
Subfield: Plant Science
Domain: Life Sciences
SDG: Zero hunger
Open Access status: hybrid
Estimated APC paid: $2,676
Awards: The Contribution of Phytophthora effectors to host range and non-host resistance, UK-China partnership to develop durable late blight disease resistance in potato, The Contribution of Phytophthora effectors to host range and non-host resistance, Controlling important diseases in potato by cloning functional NB-LRR-type resistance genes, What are the roles of oomycete RXLR effectors in the establishment of plant disease?, G4424333006, G5643051827, G5966211626, Undermining effector-targeted susceptibility factors to provide late blight resistance, New approaches to undermine late blight disease by exploiting an understanding of ubiquitin E3 ligases that positively regulate immunity, Defining and deploying Rpi gene diversity in S. americanum to control late blight in potato, G8851441572
OpenAlex ID: W2882986106