A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis
Year: 2018
Type: article
Abstract: Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a Japanese cohort. The locus is represented by rs6570507 located within GPR126 . To ensure the association of rs6570507 with AIS, we conducted a meta-analysis using eight cohorts from East Asia, Northern Europe and USA. The analysis included a total of 6,873 cases and 38,916 controls and yielded significant association (combined P = 2.95 × 10 −20 ; odds ratio = 1.22), providing convincing evidence of the worldwide association between rs6570507 and AIS susceptibility. In silico analyses strongly suggested that GPR126 is a susceptibility gene at this locus.
Source: Scientific Reports
Authors: Ikuyo Kou, Kota Watanabe, Kota Watanabe, Yohei Takahashi, Yukihide Momozawa, Anas Khanshour, Anna Grauers, Hang Zhou, Gang Liu, Yan-Hui Fan, Kazuki Takeda, Yoji Ogura, Taifeng Zhou, Yusuke Iwasaki, Michiaki Kubo, Zhihong Wu, Morio Matsumoto, Noriaki Kawakami, Koki Uno, Teppei Suzuki, Hideki Sudo, Shohei Minami, Toshiaki Kotani, Manabu Ito, Haruhisa Yanagida, Hiroshi Taneichi, Ikuho Yonezawa, Kazuhiro Chiba, Naobumi Hosogane, Nobuyuki Fujita, Mitsuru Yagi, Katsuki Kono, Eijiro Okada, Kotaro Nishida, Kenichiro Kakutani, Tsuyoshi Sakuma, Katsumi Harimaya, Takashi Kaito, Kei Watanabe, Kei Watanabe, Yuki Taniguchi, Taichi Tsuji, Tsutomu Akazawa, Lori A. Karol, Karl E. Rathjen, Daniel J. Sucato, John G. Birch, Charles E. Johnston, Benjamin S. Richards, Brandon Ramo, Amy L. McIntosh, John A. Herring, Elisabet Einarsdottir, Juha Kere, Dongsheng Huang, Guixing Qiu, Yong Qiu, Carol A. Wise, You-Qiang Song, Nan Wu, Peiqiang Su, Paul Gerdhem, Shiro Ikegawa
Institutions: RIKEN Center for Integrative Medical Sciences, Keio University, Texas Scottish Rite Hospital for Children, Länssjukhuset Sundsvall-Härnösand, Karolinska Institutet, The First Affiliated Hospital, Sun Yat-sen University, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, University of Hong Kong, Meijo Hospital, Kobe Medical Center, National Hospital Organization, Hokkaido University, Seirei Sakura Citizen Hospital, National Hospital Organization Hokkaido Medical Center, Fukuoka Children's Hospital and Medical Center for Infectious Diseases, Dokkyo University, Dokkyo Medical University, Juntendo University, Juntendo University Hospital, National Defense Medical College Hospital, National Defense Medical College, Saiseikai Central Hospital, Kobe University, Kyushu University Beppu Hospital, The University of Osaka, Niigata University Medical and Dental Hospital, University of Tokyo Hospital, The University of Tokyo, Toyota Kosei Hospital, St. Marianna University School of Medicine, University of Helsinki, Guy's Hospital, King's College London, Sun Yat-sen University, Sun Yat-sen Memorial Hospital, Nanjing Drum Tower Hospital, Nanjing University, The University of Texas Southwestern Medical Center, Karolinska University Hospital
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: Scoliosis Research Society, Japan Agency for Medical Research and Development, Milstein Medical Asian American Partnership Foundation, Vetenskapsrådet, Peking Union Medical College Hospital, Peking Union Medical College, National Institutes of Health, Japan Society for the Promotion of Science, Beijing Nova Program, Health and Medical Research Fund, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W2883170599