Work

Influence of total low dose fractionated radiation on growth and metastasis of mice Lewis lung carcinoma

Year: 2015

Type: article

Abstract: Effects of prolonged fractionated ionized radiation in low doses on the growth and metastasis intensity of mice Lewis lung carcinoma (LLC) are studied. On the background of tumor growth, stimulation induced by irradiation in the selected mode of dose fractionation inhibition of spontaneous dissemination of tumor cells into lungs is observed. On the 23-rd day after cell inoculation metastases incidence in irradiated animals was 25 % lower; the number and size of lung metastases decreased by 1.6 and 1.7 times. In the remote terms of tumor growth inhibition of functional activity of macrophages – central effectors of non-specific anti-tumor immunity was revealed.

Source: Nuclear Physics and Atomic Energy

DOI: 10.15407/jnpae2015.02.164

Authors: N.M. Ryabchenko, O.B. Ganzha, M.O. Druzhyna

Institutions: National Academy of Sciences of Ukraine, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

Language: English

Topic: Effects of Radiation Exposure

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2883397429