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Invasive Candidiasis in the Elderly: Considerations for Drug Therapy

Year: 2018
Type: review
Abstract: Candida infections in the elderly are an important and expanding clinical problem, with significantly higher mortality in this group than in younger patients. The increasing problem of invasive Candida infections may be related to higher prevalence of immunocompromised older people and the emergence of treatment resistance. Older people, especially the frail and critically ill, are at higher risk of medication-related harmful effects due to changes in pharmacokinetics and pharmacodynamics, which may be further complicated by organ dysfunction, diminished homeostatic control, co-morbidities and polypharmacy. Here, we review the available options for the treatment of Candida infections and provide insights into the challenges surrounding the optimal use of antifungal drugs in the elderly.
DOI: 10.1007/s40266-018-0576-9
Authors: B. G. J. Dekkers, A. Veringa, D. J. E. Marriott, J. M. Boonstra, K. C. M. van der Elst, F. F. Doukas, A. J. McLachlan, Jan-Willem C. Alffenaar
Institutions: University Medical Center Groningen, University of Groningen, St Vincent's Hospital Sydney, Ziekenhuis Groep Twente, The University of Sydney, Concord Repatriation General Hospital
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,990
OpenAlex ID: W2884889633
FWCI: 0.209
Cites: 74
Cited by: 40
Related to: 10