Work

Hypepontine, a new quaternary alkaloid with antimicrobial properties

Year: 2018

Type: article

Abstract: New isoquinoline alkaloid hypepontine (1) together with a five known compounds, were identified in Hypecoum ponticum Velen, the partial synonym of Hypecoum procumbens L. The structure of the new substance was elucidated based on spectroscopic evidence. The tertiary and quaternary alkaloid mixtures as well as the isolated alkaloids were evaluated for their antibacterial and antifungal activity. The result revealed that the crude alkaloid mixture containing quaternary isoquinoline alkaloids showed potent antifungal and antibacterial activity.

Source: Natural Product Research

DOI: 10.1080/14786419.2018.1495640

Authors: Tsvetelina Doncheva, Nadezhda Kostova, Violeta Valcheva, Radostina Toshkovska, Vassil Vutov, Stefan Philipov

Institutions: Bulgarian Academy of Sciences, Institute of Organic Chemistry with Centre of Phytochemistry, National Museum of Natural History

Language: English

Topic: Berberine and alkaloids research

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W2886286232

FWCI: 0.589

Cites: 10

Cited by: 18

Related to: 10