Year: 2016
Type: article
Abstract: In-situ gelation is a process of gel formulation at the site of application, in which a drug product formulation that exist as a liquid has been transformed into gel upon contact with body fluid or at body temperature.The key objective of this study was to formulate and evaluate in-situ ocular gel of Gatifloxacin using HPMC, HPMC K15M, Carbopol 934 as polymers.In-situ ocular gel was prepared by different combination of drug and excipients.Formulation was evaluated in terms of pH, gelling capacity, viscosity, Drug content estimation and in vitro drug release etc. Results indicated that HPMC K15M and carbopol 934 in combination increase the precorneal residence time and prolong the drug release.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2887216625