Year: 2018
Type: article
Study design: Observational Study
Abstract: Redox-active metals are thought to be implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). To address this point, we measured the concentrations of 12 elements and, for the first time, the stable isotope compositions of copper (redox-active) and zinc (redox-inactive) in human cerebrospinal fluids of 31 patients with ALS, 11 age-matched controls (CTRL), and 14 patients with Alzheimer disease. We first show that metal concentrations weakly discriminate patients with ALS from the two other groups. We then report that zinc isotopic compositions are similar in the three groups, but that patients with ALS have significantly 65copper-enriched isotopic compositions relative to CTRL and patients with AD. This result unambiguously demonstrates that copper is implicated in ALS. We suggest that this copper isotopic signature may result from abnormal protein aggregation in the brain parenchyma, and propose that isotopic analysis is a potential tool that may help unraveling the molecular mechanisms at work in ALS.
Source: iScience
Institutions: École Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université de Lyon, Laboratoire de Géologie de Lyon : Terre, Planètes et Environnement, Hospices Civils de Lyon, Hôpital Pierre Wertheimer, Inserm, Centre de Recherche en Neurosciences de Lyon, Lyon 1 Université, Institut des Sciences Cognitives Marc Jeannerod, Institut NeuroMyoGène
Language: English
Topic: Trace Elements in Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,240
Funders: Association Française contre les Myopathies, Fondation Neurodis, Institut National de la Santé et de la Recherche Médicale, École Polytechnique Fédérale de Lausanne, Centre National de la Recherche Scientifique, Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone
OpenAlex ID: W2887936129