Work

Mitochondrial inner membrane protein, Mic60/mitofilin in mammalian organ protection

Year: 2018

Type: review

Abstract: The identification of the mitochondrial contact site and cristae organizing system (MICOS) in the inner mitochondrial membrane shed light on the intricate components necessary for mitochondria to form their signature cristae in which many protein complexes including the electron transport chain are localized. Mic60/mitofilin has been described as the core component for the assembly and maintenance of MICOS, thus controlling cristae morphology, protein transport, mitochondrial DNA transcription, as well as connecting the inner and outer mitochondrial membranes. Although Mic60 homologs are present in many species, mammalian Mic60 is only recently gaining attention as a critical player in several organ systems and diseases with mitochondrial-defect origins. In this review, we summarize what is currently known about the ever-expanding role of Mic60 in mammals, and highlight some new studies pushing the field of mitochondrial cristae organization towards potentially new and exciting therapies targeting this protein.

Source: Journal of Cellular Physiology

DOI: 10.1002/jcp.27314

Authors: Yansheng Feng, Ngonidzashe B. Madungwe, Jean C. Bopassa

Institutions: The University of Texas at San Antonio Health Science Center, Henan Medical University, The University of Texas at San Antonio

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Heart, Lung, and Blood Institute, Center for Scientific Review