Cerebello-thalamo-cortical hyperconnectivity as a state-independent functional neural signature for psychosis prediction and characterization
Year: 2018
Type: article
Abstract: Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge in clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict the onset of psychosis and distinguish patients from healthy controls, regardless of paradigm. Here, using multi-paradigm fMRI data from the North American Prodrome Longitudinal Study consortium, we show that individuals at clinical high risk for psychosis display an intrinsic "trait-like" abnormality in brain architecture characterized as increased connectivity in the cerebello-thalamo-cortical circuitry, a pattern that is significantly more pronounced among converters compared with non-converters. This alteration is significantly correlated with disorganization symptoms and predictive of time to conversion to psychosis. Moreover, using an independent clinical sample, we demonstrate that this hyperconnectivity pattern is reliably detected and specifically present in patients with schizophrenia. These findings implicate cerebello-thalamo-cortical hyperconnectivity as a robust state-independent neural signature for psychosis prediction and characterization.
Source: Nature Communications
Authors: Hengyi Cao, Oliver Y. Chén, Yoonho Chung, Jennifer K. Forsyth, Sarah C. McEwen, Dylan G. Gee, Carrie E. Bearden, Jean Addington, Bradley Goodyear, Kristin S. Cadenhead, Heline Mirzakhanian, Barbara A. Cornblatt, Ricardo E. Carrión, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Aysenil Belger, Larry J. Seidman, Heidi Thermenos, Ming T. Tsuang, Theo G. M. van Erp, Elaine F. Walker, Stephan Hamann, Alan Anticevic, Scott W. Woods, Tyrone D. Cannon
Institutions: Yale University, University of California, Los Angeles, University of Calgary, University of California San Diego, Zucker Hillside Hospital, University of California, San Francisco, University of North Carolina at Chapel Hill, Beth Israel Deaconess Medical Center, Harvard University, University of California, Irvine, Emory University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $6,990
Awards: G2013830086, Enhancing the Prospective Prediction of Psychosis, G2648924325, G2889795720, 3/9- Predictors and Mechanisms of Conversion to Psychosis, "1/9-Predictors and Mechanisms of Conversion to Psychosis, G4367214357, G4435786034, 8/9 Predictors and Mechanisms of Conversion to Psychosis, Enhancing the Prospective Prediction of Psychosis, G5239053115, G5370752804, G5415887417, Functional Brain Abnormalities in the Schizophrenia Prodrome, G5914148781, Biological Mechanisms of Enhanced Neuroplasticity in First-Episode Schizophrenia, G6607468898, 4/9-Predictors and Mechanisms of Conversion to Psychosis, G7273892977, Harvard Clinical and Translational Science Center (UL1), 6/9-Predictors and Mechanisms of Conversion to Psychosis, Center for Neurocognition and Emotion in Schizophrenia, G8398904243, 2/9 - Predictors and Mechanisms of Conversion to Psychosis, G908804559
OpenAlex ID: W2890664143