Acetaminophen (Paracetamol) Exposure During Pregnancy and Pubertal Development in Boys and Girls From a Nationwide Puberty Cohort
Year: 2018
Type: article
Study design: Observational Study
Abstract: This study explored the association between exposure to acetaminophen during pregnancy and pubertal development using data from 15,822 boys and girls in the longitudinal Puberty Cohort, nested within the Danish National Birth Cohort. Use of acetaminophen was reported 3 times during pregnancy and 6 months postpartum. In total, 54% of mothers indicated use at least once during pregnancy. Between 2012 and 2017, sons and daughters provided information on a wide range of pubertal milestones-including Tanner stages, axillary hair growth, and age at menarche or voice break and first ejaculation-every 6 months from 11 years of age until full sexual maturation. Data were analyzed using a regression model for interval-censored data, providing adjusted mean monthly differences in age at attaining the pubertal milestones according to intrauterine cumulative (weeks) and trimester-specific acetaminophen exposure. Our results suggested a tendency towards slightly earlier attainment of almost all studied markers of female pubertal development with increasing number of weeks of exposure (i.e., about 1.5-3 months earlier age at pubic hair, axillary hair, and acne development comparing unexposed with those prenatally exposed for more than 12 weeks). Male pubertal development had no strong association with acetaminophen exposure.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwy193
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,856
Funders: March of Dimes Foundation, Aarhus Universitet, Aarhus Universitetshospital, Sundhed og Sygdom, Det Frie Forskningsråd, Innovationsfonden, National Research Foundation, Danmarks Grundforskningsfond, Lundbeckfonden, Novo Nordisk, Nordea-fonden, Danmarks Frie Forskningsfond, Egmont Fonden, H. Lundbeck A/S, University of California, Los Angeles, Medical Research Council, Fielding School of Public Health, University of California Los Angeles
Awards: G1031846133, G1099345513, G1293115906, G1615615194, G1749882372, G1936523031, G2073588333, G2131399289, G2145814837, G2193368973, G2384235469, G2642389388, G2693035121, G3233039117, G3276785593, G3342218268, G3814547547, G4117695673, G425496590, G4918890226, G5369471226, G5692678496, G5702547812, G5849383024, G5979485127, G6947076504, G7088383309
OpenAlex ID: W2890695467