Year: 2018
Type: article
Abstract: The number of overweight people worldwide is steadily growing.Obesity has become a serious health problem even in developing countries where infectious diseases are still highly prevalent.However, the interactions between these two conditions are still unclear.It is known that, during obesity, lipid deposits induce metabolic alterations associated with increased proinflammatory status, which disrupts the body hemostasis and could impair the immune responses against microorganisms.Moreover, studies in humans and animal models with infectious diseases have demonstrated that obesity usually correlates with increased susceptibility to bacterial, viral and protozoa parasite infections.In this mini-review, we will discuss some few studies that characterized the interactions between obesity and infections to clarify why obesity-associated inflammation results in impaired protective immunity.
Source: Journal of Infectiology
Authors: Licia Torres, Vinicius Martins, Ana Faria, Tatiani Maioli
Institution: Universidade Federal de Minas Gerais
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2891578956