Year: 2018
Type: article
Study design: Observational Study
Abstract: Background: Haemophilus influenza is a leading cause of community acquired bacterial meningitis and other infections, primarily in children <5 years.Here, we present the main features of Hi meningitis and analyze the effects of continuing and massive vaccination in Cuban infants and young children.Methods: A 19 years observational study of 312 cases of Hi meningitis in children <5 years old was carried out (January 1 st , 1998-December 31 st , 2016).Incidence and case-fatality rate was estimated annually, by age and province, as well as monthly distribution.Results: Overall incidence was 3.4/10 5 population in infants (with biggest proportions at 6,4 and 7 months) and1.4/10 5 in young children, with marked decreasing trend in both.Study period case-fatality rate was near 13.7% in infants and around the half in young children with marked annually variations.All provinces decreased and maintain reduction of morbidity and mortality after vaccination.Conclusion: Major decline in Hi meningitis morbidity and mortality confirmed the correctness and effectiveness of preventive strategy implemented in Cuba.Is worthwhile to continue the surveillance in order to identify changes in behavior of these life-threatening infections as well as circulating agents.
Author: Félix O Dickinson
Institution: Instituto de Medicina Tropical “Pedro Kourí”
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2895834324