EP03.13: Perinatal outcome of histologic chorioamnionitis in women with preterm premature rupture of membranes
Year: 2018
Type: conference-abstract
Abstract: This study was aimed to predict histologic chorioamnionitis based on laboratory results and ultrasonographic parameters in women diagnosed with preterm premature rupture of membranes. This retrospective case-control study included women with PPROM from 23+0 to 32+6 weeks of gestation, who delivered at Korea University Hospital in Ansan from Jan. 2006 to Dec. 2017. The maternal characteristics, neonatal characteristics and neonatal outcome variables were compared between histologically confirmed chorioamnionitis group and control group. Diagnosis of histological chorioamnionitis was made using histologic examination of placentas. Women with multiple gestations, diagnosed fetal congenital anomalies and absence of pathologic results of placenta were excluded from this study. A total of eighty-four women with PPROM were analysed. There were no significant differences between two groups in latency, time from rupture of membrane to delivery, oligohydramnios (AFI<5), diagnosed IIOC and cervical length. Incidence of the clinical chorioamnionitis was significantly higher in histologic chorioamnionitis (p-value<0.001). Neonatal outcomes (5min Apgar score less than 7, ventilator care, sepsis, NEC, RDS, PVL, BPD, IVH grade 3 to 4 and neonatal death) demonstrated no significant difference between two groups. There were significant differences in CRP, WBC and neutrophil count between two groups. Higher WBC, neutrophil count and CRP at admission in women with PPROM are associated with histological chorioamnionitis, but no significant increased neonatal morbidity and mortality were observed in histological chorioamnionitis.
DOI: 10.1002/uog.19818
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2895838728