Year: 2018
Type: article
Abstract: Oncogenic viruses are responsible by development of tumors as Human papillomavirus (HPV) that infect the anogenital epithelium causing cervical cancer, anal and penis cancer.There are viral groups based on their oncogenic activity as high-risk types, low-risk types and types of undetermined-risk.Several biotechnological assays are based on the production of recombinant products originated by the interaction of a viral genome with the genome of a host cell as bacteria, yeast, cell cultures and insects.Recently have been used virus-like particles (VLP) independently of the viral genome since some viral particles have the ability to self-assembling.There are some approved VLP vaccines as HPV vaccines, Hepatitis B and E vaccines and other VLP based vaccines under development such as using Human B19 parvovirus-like particles, Influenza vaccine candidates, Norwalk virus, Ebola and Marbug virus, Hepatitis C, Human immunodeficiency virus (HIV) as vaccine candidates.The aim of this present study was to address some examples of virus causing tumors and their respective recombinant protein based virus-like particle vaccines.Besides of HPV, also will also be addressed Hepatitis C virus (HCV), Hepatitis B virus (HBV), Herpesvirus (HSV), Herpes Simplex Virus (HSV-1) and Herpes Simplex Virus (HSV-2), Human Herpesvirus 3 (HHV-3), Human Herpesvirus 4 (HHV-4) or Epstain-Barr virus (EBV), Human Herpesvirus-5 (HHV-5) or Human Cytomegalovirus (HCMV), Human Herpesvirus 6 (HHV-6), Human Herpesvirus 7 (HHV-7) and Human Herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV).There are several challenges in the production of the virus-like particles based recombinant vaccines under development using specific cell lines and assays with laboratory animals.It is important to reflect about on the extent to which the pharmaceutical industries are willing to develop recombinant vaccines in the prevention of tumor associated diseases.
Institutions: Instituto Oswaldo Cruz, Fundação Oswaldo Cruz
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2896046463