Work

Promising New Antifungal Treatment Targeting Chorismate Synthase from Paracoccidioides brasiliensis

Year: 2018

Type: article

Abstract: ) of 47 ± 5 μM. As expected, CP1 showed no toxicity in three cell lines. On the other hand, CP1 reduced the fungal burden in lungs from treated mice, similar to itraconazole. In addition, histopathological analysis showed that animals treated with CP1 displayed less lung tissue infiltration, fewer yeast cells, and large areas with preserved architecture. Therefore, CP1 was able to control PCM in mice with a lower inflammatory response and is thus a promising candidate and lead structure for the development of drugs useful in PCM treatment.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01097-18

Authors: Franciele Abigail Vilugron Rodrigues-Vendramini, Cidnei Marschalk, Marina Toplak, Peter Macheroux, Patricia de Souza Bonfim-Mendonça, Terezinha Inez Estivalet Svidzinski, Flavio Augusto Vicente Seixas, Erika Seki Kioshima

Institutions: Universidade Estadual de Maringá, Graz University of Technology

Language: English

Topic: Fungal Infections and Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2896072016

FWCI: 2.787

Cites: 65

Cited by: 37

Related to: 10