Work

Impact of Charlson comorbidity index on survival of octogenarian patients with colorectal cancer

Year: 2018

Type: article

Abstract: Background: Octogenarians have higher rates of comorbidity that are associated with a poor prognosis. Few studies have identified prognostic factors of elderly patients (pts) with colorectal cancer (CRC), so their optimized care strategies remain controversial. Charlson comorbidity index (CCI) is the most widely used clinical scoring system to predict the survival of patients with malignancies. The aim of this study was to investigate the prevalence of comorbidity and the prognostic impact of the CCI score for survival among octogenarian pts with CRC in our center. Methods: We reviewed 151 pts referred to Medical Oncology between January 2012 and March 2017. Data on demographics, staging, treatment and survival were collected and analysed. CCI score was independent variable. OS rates was estimated by the Kaplan–Meier method, with differences in survival between groups compared by the log-rank test. Results: We reviewed 151 pts with CRC referred to Medical Oncology between January 2012 and March 2017. Data on demographics, staging, treatment and survival was collected and analysed. CCI score was the independent variable. OS rates was estimated by the Kaplan–Meier method, with differences in survival between groups compared by the log-rank test. Results Octogenarians were a 19% of all pts, 82 (54%) men and 69 (46%) women. The median age was 84 years. There was no difference in performance status (PS) between genders with PS 0-1 in 76%, PS 2 in 26% and PS 3-4 in 10%. Pts were divided into high CCI score (CCI ≥ 3; n = 52) and low CCI score (CCI < 3; n = 99) groups for comparative analyses of differences in their short- and long-term outcomes. The overall survival (OS) in pts with a Low CCI Score was longer than that in high CCI score (46 versus 25 months; p < 0.01). High CCI score significantly relates to poorer survival outcome for all stages (p < 0.001).Table: 592PCharacteristicsLow CCI group (n = 99)High CCI group (n = 52)p valueSex (male/female)46/5323/290.74Stage at diagnosis I II III IV10 21 39 296 7 16 230.003Primary tumor location Right Left Rectum38 44 1724 17 110.24 Open table in a new tab Conclusions: In our study CCI score (low or high) showed be independent factor in prognosis and survival in octogenarian patients with colorectal cancer. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.

Source: Annals of Oncology

DOI: 10.1093/annonc/mdy281.138