Work

Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care

Year: 2018

Type: article

Abstract: Gastrointestinal cancer is one of the most common causes of mortality globally. The present study examined the influence of cytokine genetic polymorphisms [interleukin (IL)‑1B C‑31T, IL‑1RN VNTR, IL‑6 C‑634G, IL‑8 T‑251A, IL‑10 T‑819C and IL‑10 A‑1082G] on clinical outcomes in patients with gastrointestinal cancer in palliative care. A total of 59 patients with gastrointestinal cancer who were admitted to Iga City General Hospital were analyzed. Genotyping was conducted using a polymerase chain reaction with confronting two‑pair primers. Patients with at least one IL‑1RN 2 allele demonstrated a significantly better survival (P=0.0275) while those with IL‑6‑634 G/G demonstrated a worse survival (P=0.0024). Multivariate analyses using the Cox proportional hazard model revealed that those with at least one IL‑1RN 2 allele, IL‑6‑634 G/G or IL‑10‑1082 A/G had a significantly elevated adjusted hazard ratio of 9.20 (P=0.014), 41.01 (P=0.001) or 6.49 (P=0.046), respectively, compared with those with each homozygous wild‑type polymorphism. In addition, the evaluation of weight loss by genotype revealed the potential influence of IL‑10 T‑819C genotype (P=0.072). IL‑1RN, IL‑6 and IL‑10 polymorphisms were associated with the survival of patients with gastrointestinal cancer, suggesting the clinical feasibility of genetic testing in patients with gastrointestinal cancer in palliative care.

Source: Oncology Letters

DOI: 10.3892/ol.2018.9614