Work

Deciphering the effect of reproductive tract microbiota on human reproduction

Year: 2018

Type: review

Abstract: BACKGROUND: genus, which is associated with a healthy microbiome state. However, spatio-temporal fluctuations of this microbiome that occur in response to internal and external factors may impact the physiology of the reproductive tract organs and even lead to pathological states. METHODS: Current literature covering the reproductive tract microbiome is summarized and contextualized in this review. MAIN FINDINGS: This review presents the current knowledge about the bacterial composition of the lower and upper reproductive tract as well as the impact of the microbiota on women's health and reproduction. We place special focus on the impact of the endometrial microbiome in infertility and assisted reproductive technologies. CONCLUSION: The assessment of the reproductive tract microbiome adds a new microbiological perspective to human reproduction, pregnancy, and onset of new life, highlighting the importance of considering the evaluation of microbial communities to improve personalized care in reproductive medicine and women's health.

Source: Reproductive Medicine and Biology

DOI: 10.1002/rmb2.12249

Authors: Inmaculada Moreno, Carlos Simon

Institutions: Igenomix, Universitat de València, Stanford Medicine, INCLIVA Health Research Institute, Stanford University

Language: English

Topic: Reproductive tract infections research

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,850