Work

Bioavailability Enhancement for Poorly Soluble Drugs: a Review

Year: 2018

Type: review

Abstract: Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. Drug with poor water solubility cause slow dissolution rates, generally show erratic and incomplete absorption leading to low bioavailability when administered orally. This present review details about the different approaches used for the enhancement of the solubility of poorly water-soluble drugs. The purpose of this article is to describe the techniques of solubilization for the attainment of effective absorption and improved bioavailability. Keywords: Solubility, bioavailability, absorption, solubilization

Source: International Journal of Sciences

Authors: Chinmaya Keshari Sahoo, G. Santhoshini Reddy, Abhignya Vojjala, Buchanpally Vikram Reddy

Institutions: Malla Reddy Vishwavidyapeeth, Osmania University

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: diamond

OpenAlex ID: W2899220175

FWCI: 0.069

Cites:

Cited by: 6

Related to: 10