Year: 2018
Type: article
Study design: Case Report
Abstract: Anaphylaxis with midazolam in pediatric hematologyoncology unit: a case reportDear Editor, Four courses of chemotherapy were given to a 17-yearold male patient (body weight 73 kg) who was being followed up with a diagnosis of acute myeloid leukemia in our Pediatric Hematology-Oncology Clinic and bone marrow aspiration and lumbar puncture were performed before each course.Throughout these treatments, sedation was provided with midazolam seven times and bone marrow aspiration and lumbar puncture were performed.The patient had no known history of drug allergy or food allergy.The patient was taken into the intervention room before the fifth course of therapy for ordinary bone marrow aspiration and lumbar puncture.Before the procedure, 5 mg midazolam was administered by the intravenous route for the objective of sedation.In the first minute after the drug was administered, vomiting, dyspnea, and chest pain developed and hypotension (80/40 mm Hg) occurred.A diffuse urticarial rash appeared on the body and edema developed in the face and upper part of the neck.It was thought that an anaphylaxis-like reaction against midazolam had occurred; 0.5 mg adrenaline and 40 mg methylprednisolone were administered intravenously and 100% oxygen was given by mask.Adrenaline and methylprednisolone were administered again because hypotension continued, and 500 mL normal saline was loaded with rapid infusion.After fifteen minutes, the patient's vital values became normal, the interventional procedures were postponed and he was taken to his room.
Source: Türk Pediatri Arşivi
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2901201044