Year: 2018
Type: article
Study design: Observational Study
Abstract: Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre‐diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. We used pre‐diagnostic biomarker data from 5183 case–control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls. Exposures included directly measured circulating vitamin B12 in pre‐diagnostic blood samples from the nested case–control study, and 8 single nucleotide polymorphisms associated with vitamin B12 concentrations in the MR study. Our main outcome of interest was increased risk for lung cancer, overall and by histological subtype, per increase in circulating vitamin B12 concentrations. We found circulating vitamin B12 to be positively associated with overall lung cancer risk in a dose response fashion (odds ratio for a doubling in B12 [ORlog2B12] = 1.15, 95% confidence interval (95%CI) = 1.06–1.25). The MR analysis based on 8 genetic variants also indicated that genetically determined higher vitamin B12 concentrations were positively associated with overall lung cancer risk (OR per 150 pmol/L standard deviation increase in B12 [ORSD] = 1.08, 95%CI = 1.00–1.16). Considering the consistency of these two independent and complementary analyses, these findings support the hypothesis that high vitamin B12 status increases the risk of lung cancer.
Source: International Journal of Cancer
DOI: 10.1002/ijc.32033
Authors: Anouar Fanidi, Robert Carreras‐Torres, Tricia L. Larose, Jian‐Min Yuan, Victoria L. Stevens, Stephanie J. Weinstein, Demetrius Albanes, Ross Prentice, Mary Pettinger, Qiuyin Cai, William J. Blot, Alan A. Arslan, Anne Zeleniuch‐Jacquotte, Marjorie L. McCullough, Loic Le Marchand, Lynne R. Wilkens, Christopher A. Haiman, Xuehong Zhang, Meir J. Stampfer, Stephanie A. Smith‐Warner, Edward Giovannucci, Graham G. Giles, Allison M. Hodge, Gianluca Severi, Mikael Johansson, Kjell Grankvist, Arnulf Langhammer, Ben M. Brumpton, Renwei Wang, Yu‐Tang Gao, Ulrika Ericson, Stig E. Bojesen, Susanne M. Arnold, Woon‐Puay Koh, Xiao‐Ou Shu, Yong‐Bing Xiang, Honglan Li, Wei Zheng, Qing Lan, Kala Visvanathan, Judith Hoffman‐Bolton, Per M. Ueland, Øivind Midttun, Neil E. Caporaso, Mark Purdue, Neal D. Freedman, Julie E. Buring, I‐Min Lee, Howard D. Sesso, J. Michael Gaziano, Jonas Manjer, Caroline L. Relton, Rayjean J. Hung, Chris I. Amos, Mattias Johansson, Paul Brennan
Institutions: University of Cambridge, MRC Epidemiology Unit, Centre international de recherche sur le cancer, Norwegian University of Science and Technology, University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, American Cancer Society, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Fred Hutch Cancer Center, Vanderbilt University, Vanderbilt-Ingram Cancer Center, International Epidemiology Institute, New York University, University of Hawaiʻi at Mānoa, University of Hawaii System, University of Southern California, Brigham and Women's Hospital, Harvard University, The University of Melbourne, Cancer Council Victoria, Inserm, Centre de recherche en Epidémiologie et Santé des Populations, Italian institute for Genomic Medicine, Umeå University, Shanghai Jiao Tong University, Shanghai Cancer Institute, Lund University, University of Kentucky, Markey Cancer Center, National University of Singapore, Duke-NUS Medical School, Johns Hopkins University, Haukeland University Hospital, University of Bergen, Bevital (Norway), VA Boston Healthcare System, Skåne University Hospital, University of Bristol, MRC Integrative Epidemiology Unit, Newcastle University, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Dartmouth College
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: World Health Organization, Division of Cancer Prevention, National Cancer Institute, Centre International de Recherche sur le Cancer, Norges Teknisk-Naturvitenskapelige Universitet, Cancer Care Ontario, Cancer Research UK, Norges Forskningsråd, National Institutes of Health, Medical Research Council, National Cancer Institute
Awards: G1131969086, Prospective studies of cancer etiology and prevention in Shanghai and Singapore, THE SINGAPORE COHORT STUDY OF DIET AND CANCER, G3344456887, One-carbon metabolism biomarkers and lung cancer risk, Integrative Analysis of Lung Cancer Etiology and Risk, DIETARY FACTORS IN THE ETIOLOGY OF CANCER IN SHANGHAI, The NYU Women's Health Study, Transdisciplinary Research in Cancer of the Lung (TRICL), G5819568706, G6682065591, Epigenetic Epidemiology, Cancer epidemiology cohorts in Shanghai and Singapore , G76752795, Women's Health Study: Infrastructure support for cohort follow-up, Shanghai Womens Health Study, G9000131883, University of Hawaii Cancer Center CCSG
OpenAlex ID: W2902012279