Work

Design, synthesis, and biological activity of novel ammonium salts containing sterically hindered phenolic fragment and phosphoryl group

Year: 2018

Type: article

Abstract: 855-653 in the concentration range of 442-0.70 μM. The maximum activity of an ammonium salt among all the types of structure was observed in cases in which a decyl radical was present on the onium nitrogen atom. The most active compounds exhibited antioxidant activity at levels of 0.25 and 0.50 mM and did not display cytotoxic properties towards WI-38 (human embryonic lung cells) and Chang liver (human liver cells) cell lines in the concentration range of 0.70-11.3 μM.

Source: MedChemComm

DOI: 10.1039/c8md00481a

Authors: Ramilya R. Starodubtseva, Elmira M. Gibadullina, Nurbala B. Pazilova, Anastasiia S. Sapunova, Alexandra D. Voloshina, Igor A. Sudakov, Alexandra B. Vyshtakalyuk, Michael A. Pudovik, Alexander R. Burilov, Sergey V. Bukharov

Institutions: Kazan Scientific Center, A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan State Technical University named after A. N. Tupolev

Language: English

Topic: Free Radicals and Antioxidants

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2902016867

FWCI: 0.881

Cites: 41

Cited by: 19

Related to: 10