Work

Elucidating the multiple structures of pipecolic acid by rotational spectroscopy

Year: 2018

Type: article

Abstract: The complex conformational space of the non-proteinogenic cyclic amino acid pipecolic acid has been explored in the gas phase for the first time. Solid pipecolic acid samples were vaporized by laser ablation and expanded in a supersonic jet where the rotational spectral signatures owing to nine different conformers were observed by Fourier transform microwave spectroscopy. All species were identified by comparison of the experimental rotational and nuclear quadrupole coupling constants with those predicted theoretically. Observation of type-III conformers, leading to a difference when compared against the conformational behavior of the analog amino acid proline, has been interpreted by an increment in steric hindrance when increasing the number of carbons present in the ring.

Source: Physical Chemistry Chemical Physics

DOI: 10.1039/c8cp06120c

Authors: A. Simão, C. Cabezas, I. León, E. R. Alonso, S. Mata, J. L. Alonso

Institutions: Universidad de Valladolid, Consejo Superior de Investigaciones Científicas, Universitat de València

Language: English

Topic: Molecular Spectroscopy and Structure

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Ministerio de Ciencia e Innovación, Consejería de Educación, Junta de Castilla y León, Fundação para a Ciência e a Tecnologia, FP7 Ideas: European Research Council