MetProc: Separating Measurement Artifacts from True Metabolites in an Untargeted Metabolomics Experiment
Year: 2018
Type: article
Abstract: High-throughput metabolomics using liquid chromatography and mass spectrometry (LC/MS) provides a useful method to identify biomarkers of disease and explore biological systems. However, the majority of metabolic features detected from untargeted metabolomics experiments have unknown ion signatures, making it critical that data should be thoroughly quality controlled to avoid analyzing false signals. Here, we present a postalignment method relying on intermittent pooled study samples to separate genuine metabolic features from potential measurement artifacts. We apply the method to lipid metabolite data from the PREDIMED (PREvención con DIeta MEDi-terránea) study to demonstrate clear removal of measurement artifacts. The method is publicly available as the R package MetProc, available on CRAN under the GPL-v2 license.
Source: Journal of Proteome Research
Institutions: Harvard University, Carnegie Mellon University, Broad Institute, Instituto de Salud Carlos III, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Universidad de Navarra, Institut de Recerca Biomèdica Catalunya Sud, Hospital Universitari Sant Joan de Reus, Universitat Rovira i Virgili, Universitat de València, Universidad de Málaga, Health Research Institute of the Balearic Islands, Hospital Del Mar, Parc de Salut, Municipal Institute for Medical Research, Hospital del Mar Research Institute, Universidad de Las Palmas de Gran Canaria
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: Generalitat de Catalunya, Fundación Mapfre, Generalitat Valenciana, Ministerio de Ciencia e Innovación, Centro Nacional de Investigaciones Cardiovasculares, Junta de Andalucía, Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, Gobierno de Navarra, National Institutes of Health, Instituto de Salud Carlos III, European Regional Development Fund, National Heart, Lung, and Blood Institute
Awards: G122220256, G1240442146, G1279912698, G1298808146, G1372021016, G1442347428, G1469509158, G1526370294, G1553903662, G1559608605, G1602877980, G1607730991, G1617498335, G1631326430, PREDIMED-PLUS: efecto de una dieta mediterránea hipocalórica y promoción de la actividad física en prevención primaria cardiovascular. Estudio piloto sobre marcadores intermedios, G1644185098, G1881394406, G1916957000, G1940426220, G1952594217, G1982901712, G2174794381, G2266513321, G2297909926, G2301868462, G2389799761, G244262120, G247774864, G2580699549, G2619058490, G2620658983, G2645070709, G2647692628, G2682004843, G2684494655, G2687621885, G2703367647, G2752920621, G2784830948, G2807603561, G2812572595, G2829840012, G2860824219, G2971060662, G3011546996, G3057871547, G3059837661, G316735455, G3197366600, G3205439833, G3232365121, G3434072752, G346601977, G3688119456, G3742009404, G3848398977, G3943872819, G3979033006, G399063081, G4019470342, G4043953188, G4144917788, G4159188393, G4162932109, G4176854398, G4268175729, G4277448938, G4282990219, G4418385139, G4437166959, G4487147551, G4489531123, G4494103574, G4508165138, G4587032617, G4654025265, G4662533551, G4786509053, G5015966996, G5328429606, G5428270377, G5542193060, G5589077169, G5704818146, G5919349966, G6047342578, G6109029077, G6191476278, G6259981162, G6486018093, PREDIMED-PLUS: Efecto de una dieta mediterránea hipocalórica y promoción de la actividad física en prevención primaria cardiovascular. Estudio piloto sobre marcadores intermedios, G6591504236, G6684950678, G669311712, G6695954693, G6965730286, G7028759952, G7140016538, G7170130439, G7283614615, G7298344767, G7413238183, G7427883014, G7433271767, G7508138973, G7601994061, G7657512343, G7764985876, G7785651465, G809854847, G8106377099, G8251716732, G8289360861, G831563074, G8326286816, G8426496700, G8470484741, G8672344029, G8673859687, G867847296, G8744695932, G880079747, G8947043810, G897709570, Mediterranean diet, Metabolites, and Cardiovascular Disease, G936607085, G993951910
OpenAlex ID: W2904863950