Work

Biomarkers for Immunotherapy Toxicity: Are Cytokines the Answer?

Year: 2018

Type: article

Abstract: Immune checkpoint inhibitors induce durable responses in some patients with advanced cancer but may simultaneously trigger autoinflammatory immune-related adverse events (irAE). The pathogenesis of irAEs may relate to genetic predisposition, environmental insults, or tumor–host interactions. Elevated expression of certain cytokines may signal subclinical inflammation that evolves into severe irAEs with treatment. See related article by Lim et al., p. 1557

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-18-3858

Authors: Douglas B. Johnson, Justin M. Balko

Institutions: Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute