Work

Synthesis and characterization of imidazolium ILs based chitosan–tripolyphosphate microparticles

Year: 2018

Type: conference-paper

Abstract: In this work, two imidazolium based ILs, 1–butyl–3– methylimidazolium hydrogen sulfate [bmim][HSO 4 ] and 1–butyl–3– methylimidazolium acetate [bmim][Ac] were blended with Chitosan (CS) to synthesize the CS–IL–TPP microparticles. The prepared microparticles were characterized by Zetasizer, FTIR, TGA, SEM and elemental analysis (EDX). The addition of these ILs resulted in controlled sized microparticles which possessed good thermal stability. The elemental analysis indicated that the better crosslinking of tripolyphosphate (TPP) with CS was achieved in the presence of IL, [bmim] [Ac] as compared with [bmim] [HSO 4 ] and CS–TPP formulation alone. The better crosslinking might result in the formation of stable and compact microparticles which could have a better control over the drug release applications. Therefore, this kind of IL might be suitable for improving the characteristics of chitosan as a drug carrier which could ultimately provide controlled release of unstable drugs.

Source: IOP Conference Series Materials Science and Engineering

DOI: 10.1088/1757-899x/458/1/012080

Authors: Rizwan Safdar, Abdul Aziz Omar, A. Arunagiri, Murugesan Thanabalan

Institutions: Universiti Teknologi Petronas, National Institute of Technology Tiruchirappalli

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: diamond

Funders: Universiti Teknologi Petronas, Yayasan UTP

Awards: G6601835900, G8706771436