Red Raspberry Extract Protects the Skin against UVB-Induced Damage with Antioxidative and Anti-inflammatory Properties
Year: 2019
Type: article
Abstract: Extensive exposure to UVB (280–320 nm) is the major risk responsible for various skin injuries. Numerous reports have shown that natural products could demonstrate photochemopreventive efficacy against UVB damage. We investigated the preventive effects and associated molecular mechanisms of red raspberry extract upon UVB-caused damage in human epidermal keratinocytes and a nude mouse model. The protein profiles and immunohistological study on a nude mouse skin indicated that red raspberry extract could prevent UVB-caused cell death and protect the skin against UVB-exposed injury manifested by wrinkling, scaling, tanning, and water loss as well as epidermal thickening. In addition, red raspberry extract application effectively abolished oxidative damage in DNA and attenuated the carbonylation level of proteins, which attributed to the activation of SOD, Nrf2 and its target genes, and HO-1. Red raspberry extract also altered the cells’ apoptotic signaling pathways including caspase-3 as well as the inflammatory cascade such as c-jun and attenuated UVB-induced activation of NF-κB and COX-2. Red raspberry extract could alleviate direct photodamage to the skin caused by UVB exposure through the ROS scavenger and protection against inflammatory responses, which may allow the development of novel strategies in protecting the skin subjected to UVB radiation.
DOI: 10.1155/2019/9529676
Institutions: China Medical University, China Medical University Hospital, Chang Gung University, Kaohsiung Chang Gung Memorial Hospital, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Chang Gung University of Science and Technology, Chang Gung Memorial Hospital, Taoyuan Chang Gung Memorial Hospital, Linkou Chang Gung Memorial Hospital
Language: English
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
Awards: G1086359487, G2532266991, G2720752547, G4519811768, G4652560136, G4719345118, G4878309654, G5005248943, G6221865288, G6333420759, G7796251624, Dissect the Anti- Fibrotic Efficacy and Its Microenvironment as Well as Associated Molecular Mechanisms of Sho-Saiko-To, G8261592503, G8357237546, G847728513
OpenAlex ID: W2906700432