Synthesis, Characterization and Evaluation of Biological Properties of Transition Metal Chelates with Schiff base Ligands Derived from Glutaraldehyde with L-Leucine
Year: 2018
Type: article
Abstract: A nitrogen-oxygen Schiff base HL derived from Glutaraldehyde and L-Leucine has been reacted with different divalent metal ions in 2:1 molar ratio, producing neutral complexes . All compounds were characterized using physico-chemical and spectroscopic methods namely elemental analysis, melting point, magnetic moment measurement, conductivity measurement, UV-Vis, IR, 1HNMR spectroscopy and XRD measurements. They were further analysed by thermal technique (TGA/DTA) to gain better insight about the thermal stability and kinetic properties of the complexes. The IR data demonstrated the tetradentate binding of Schiff base ligand. The molar conductivity values were relatively low , showing their nonelectrolytic nature. Room temperature magnetic susceptibility measurements revealed that the nature of Ni(II) and Cu(II) complexes were paramagnetic. The in vitro antimicrobial activities of all the compounds were screened against different microbial species by Disc Diffusion method and showed better activity compared to parent drug and control drug.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2907415393