Work

Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α 4 β 7 integrin antibody

Year: 2019

Type: article

Abstract: However, we also observed that severe T cell motility defect caused by high degrees of cofilin hyperactivation was not repairable by the anti-integrin antibody, demonstrating a mechanistic hindrance to restore immune functions in vivo. Our study suggests that cofilin is a key molecule that may need to be therapeutically targeted early for T cell tissue repopulation, immune reconstitution, and immune control of viremia.

Source: Science Advances

DOI: 10.1126/sciadv.aat7911

Authors: Sijia He, Yajing Fu, Jia Guo, Mark Spear, Jiuling Yang, Benjamin Trinité, Chaolong Qin, Shuai Fu, Yongjun Jiang, Zining Zhang, Junjie Xu, Haibo Ding, David N. Levy, Wanjun Chen, Emanuel Petricoin, Lance A. Liotta, Hong Shang, Yuntao Wu

Institutions: George Mason University, Chinese Academy of Medical Sciences & Peking Union Medical College, First Hospital of China Medical University, China Medical University, New York University, National Institutes of Health, National Institute of Dental and Craniofacial Research

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500

Funders: U.S. Department of Health and Human Services, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases

Awards: Viruis Dynamics and Multiple Infection of Cells: Computational and Experimental A, Development of a novel HIV-1 nuclear localization assay, Establishing HIV-1 chromatin in resting T cells: Vpr, latency, and H2A.Z, The contribution of unintegrated HIV-1 to latency and to models of latency, G2286104247, G7031188589, Validation of the Rev-dependent vector for targeting SIV macrophage reservoirs

OpenAlex ID: W2908522009

FWCI: 1.177

Cites: 51

Cited by: 23

Related to: 10