Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions
Year: 2019
Type: article
Abstract: We have demonstrated that tadalafil facilitates fetal growth in mice with L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia (PE) with fetal growth restriction (FGR). Tadalafil is a selective phosphodiesterase 5 inhibitor that dilates the maternal blood sinuses in the placenta, thereby facilitating the growth of the fetus. The purpose of this study was to investigate the effects of tadalafil treatment for PE and FGR on the developing brain in FGR offspring using an L-NAME-induced mouse model of PE with FGR. A control group of dams received carboxymethylcellulose (CMC). L-NAME-treated groups received L-NAME dissolved in CMC from 11 days post coitum (d.p.c.). The L-NAME-treated dams were divided into two subgroups 14 d.p.c. One subgroup continued to receive L-NAME. The other subgroup received L-NAME with tadalafil suspended in CMC. Tadalafil treatment for PE with FGR reduced the expression of hypoxia-inducible factor-2α in the placenta and in the brain of the FGR fetus. Moreover, tadalafil treatment in utero shows improved synaptogenesis and myelination in FGR offspring on postnatal day 15 (P15) and P30. These results suggest that tadalafil treatment for PE with FGR not only facilitates fetal growth, but also has neuroprotective effects on the developing brain of FGR offspring through modulating prenatal hypoxic conditions.
Source: Scientific Reports
Authors: Ryota Tachibana, Takashi Umekawa, Kento Yoshikawa, Takao Owa, Shoichi Magawa, Fumi Furuhashi, Makoto Tsuji, Shintaro Maki, Kyoko Shimada, Michiko K. Kaneda, Masafumi Nii, Hiroaki Tanaka, Kayo Tanaka, Yuki Kamimoto, Eiji Kondo, Ineko Kato, Kenji Ikemura, Masahiro Okuda, Ning Ma, Takekazu Miyoshi, Hiroshi Hosoda, Masayuki Endoh, Tadashi Kimura, Tomoaki Ikeda
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,790
Awards: Cancer-prevention by aspirin and the mechanism, from the viewpoint of inflammation-related DNA damage and cancer stem cell, Tadalafil treatment for Fetus with Early onset growth Restriction, Development of novel preventive method for cisplatin-induced nephrotoxicity with drug-drug interaction, Establishment of the molecular basis for the safety of tadalafil administration for fetal growth retardation., Analysis on the expression of protein regulating pharmacokinetics via oxidative stress-response lncRNA, A comparative molecular epidemiology study of carcinogenicity on the liver flube infection in the Xijiang (China) and Mekong river (Thailand)
OpenAlex ID: W2908591663