Work

Role of the Barrier Dysfunction of the Intestines in the Development of Alimentary Allergy in Children

Year: 2013

Type: article

Abstract: Intestinal epithelial barrier plays an important role in prevention of bacterial translocation and food allergens penetration. Article is dedicated to intestinal epithelial barrier disfunctions leading to sensitization. Special attention is paid to molecular mechanisms increasing the allergens penetration through intestinal wall. Phase of sensitization is characterized by antigen-induced crossover IgE connection with FcRI receptor on the surface of mast cell which leads to anaphylactic reaction. Key words : infants, food allergy, sensitization, intestinal epithelial barrier.

Source: Вопросы современной педиатрии

DOI: 10.15690/vsp.v12i2.615

Authors: T. E. Borovik, S. G. Makarova, G. V. Yatsyk, T. N. Stepanova, S. G. Gribakin

Institutions: Sechenov University, Scientific Center of Children's Health

Language: English

Topic: Food Allergy and Anaphylaxis Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W290904335

FWCI: 0.265

Cites: 55

Cited by: 3

Related to: 10