Genomic Epidemiology of Tuberculosis: From Within Host Evolution to Global Migration Patterns
Year: 2018
Type: article
Abstract: The availability of thousands of Mycobacterium tuberculosis genomes allows not only to infer how the pathogen emerged and spread but also to identify specific loci associated.I will present our work using evolutionary analyses to generate a high-resolution picture of the emergence, global spread and local transmission of the pathogen as well as genomic determinants associated.I will show how non-selective processes like genetic drift contribute to the genomic diversity of the pathogen with downstream consequence at the transcription and methylation levels.In the second part of the talk I will also discuss different approaches to identify and track new drug resistance determinants using a combination of functional genomics and genomic diversity analyses from different countries and from different patients through time and space.Overall our analyses reveal new bacterial factors associated to virulence and drug resistance.I will show however how the frequency of genetic variants associated to different traits, even if advantageous, depend on the conditions of local TB control more than on the high fitness of the bacterial genotype. 6.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2910545596