Combination of Cell-Penetrating Peptides with Nanoparticles for Therapeutic Application: A Review
Year: 2019
Type: review
Abstract: Cell-penetrating peptides (CPPs), also known as protein translocation domains, membrane translocating sequences or Trojan peptides, are small molecules of 6 to 30 amino acid residues capable of penetrating biological barriers and cellular membranes. Furthermore, CPP have become an alternative strategy to overcome some of the current drug limitations and combat resistant strains since CPPs are capable of delivering different therapeutic molecules against a wide range of diseases. In this review, we address the recent conjugation of CPPs with nanoparticles, which constitutes a new class of delivery vectors with high pharmaceutical potential in a variety of diseases.
Source: Biomolecules
DOI: 10.3390/biom9010022
Authors: Sara Silva, António Almeida, Nuno Vale
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,216
Awards: G1167214205, G1301869319, G1471824801, G1516346500, G1578237752, New advance in biomedicine: peptide-mediated target drug delivery, G1763632427, G198576669, G2037501035, G2130961843, G2420110423, G254011574, G274581676, Instituto de Investigação do Medicamento, G3840324753, G3891694003, G4409734977, G4724859719, G491858407, G498092695, G5224927334, G5454278309, G5677667711, G5876605032, UID/BIM/04293 .: Instituto de Investigação e Inovação em Saúde, G6521127352, G7965899483, The role of Tlx3-induced phosphorylation mechanisms in the specification of glutamartergic neuronal fate in the developing dorsal spinal cord, G82242560
OpenAlex ID: W2911207445