Year: 2019
Type: conference-abstract
Abstract: Fucosyltransferase 2 (FUT2) at 19q13 is a well-established susceptibility locus for Crohn’s disease (CD) in Caucasians. FUT2 encodes α-1,2-fucosyltransferase that is responsible for the secretion of the ABO antigens in both gastrointestinal mucosa and secretory glands. Given CD is thought to arise by dysregulated mucosal immune responses to the gut flora and both ABO blood group and the FUT2 secretor status affect the composition of the gut microbiota, the goal of this study was to evaluate associations of variants of FUT2 and ABO with Korean patients with CD. Three single-nucleotide polymorphisms from the FUT2 and ABO genes were genotyped in 1735 patients with CD and 8074 healthy controls. The influences of the FUT2 secretor status and ABO blood group on the cumulative probabilities of intestinal resection were assessed. The FUT2 non-secretor allele showed genome-wide significant association with CD in Koreans (rs1047781, OR = 1.30, pcombined = 3.52 × 10−12). The ABO locus showed genome-wide significant association with CD in Asians (pmeta = 2.35 × 10−8). Compared with the O group, moderate association was observed with the A and B groups (OR = 1.40, p = 2.26 × 10−6 and OR = 1.32, p = 1.92 × 10−4, respectively). Following stratification on the basis of FUT2 genotype, carriers of the secretor O blood group were significantly protective against CD compared with the secretor non-O blood group (OR = 0.63, 95% CI = 0.54–0.73, p = 2.86 × 10−9, Figure 1). Figure 1. Forest plot illustrates the different odds ratios and 95% confidential interval of specific blood groups between case and controls with secretor status. The cumulative probability of intestinal resection was significantly higher in patients with non-secretor status compared with those with secretor status: 38.4% vs. 33.3% at 10 years, 44.7% vs. 39.5% at 20 years, and 45.3% vs. 39.6% at 25 years (p = 0.014, Figure 2). Figure 2. Kaplan–Meier curve for comparison of cumulative probability of intestinal resection between Crohn's disease patients with secretor vs. non-secretor status. Our data show that both FUT2 and ABO loci show genome-wide significant association with CD, the FUT2 non-secretor status affects 25-year clinical outcomes, and blood group O and secretor status are protective factor against CD in Asians.
Source: Journal of Crohn s and Colitis
Institutions: University of Ulsan, KU Leuven, Asan Medical Center
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2912378906