Year: 2019
Type: review
Abstract: Functional food represents an important alternative management of atherosclerosis, its risk factors, and clinical complications. Atherosclerosis is characterized by microinflammation, formation of atheromatous lipoprotein-rich plaques, and protrombogenic status. Cornelian cherry (Cornus mas L., CC) contains polyphenols influencing all three components of atherosclerosis. Its high antioxidant potential, verified in experimental studies, exhibited a pronounced decrease of inflammatory markers. CC treatment demonstrated a favourable effect on lipid spectrum (comparable with statins), decrease of glycemia, and increase of insulin (comparable with glibenclamide). Polyphenols identified in CC exhibited both direct antiplatelet effects and reduction of platelet hyper-reactivity mediated via attenuation of oxidative stress. The first clinical trials confirmed a clinically relevant decrease of total and low-density lipoprotein cholesterol, triacylglycerols, lipoproteins, amelioration of inflammatory activity, and insulin secretion improvement after the treatment with CC polyphenolic compounds. However, the limitation of published studies is the use of undefined cultivars of CC, their experimental nature, small scale, and missing longitudinal trials. Nevertheless, biochemical properties of CC, hitherto described, predispose its products for the adjuvant management of atherosclerosis.
DOI: 10.1155/2019/2515270
Institutions: Slovak Academy of Sciences, Centre of Experimental Medicine of the Slovak Academy of Sciences, Institute of Normal and Pathological Physiology of the Slovak Academy of Sciences, Comenius University Bratislava, M.M. Gryshko National Botanical Garden of National Academy of Sciences of Ukraine
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
Awards: G1900781532, G2026007387, G2864148171, G3233818929, G3512632192, Efekt lyofilizátu Cornus mas L. na kardiometabolické a zápalové parametre pri experimentálnom metabolickom syndróme, Morfologická charakteristika zmien pri reparačných a regeneračných mechanizmoch v myokarde pri chronických chorobách, Účinok nanoenkapsulovaného simvastatínu na kardiovaskulárny systém pri experimentálnom metabolickom syndróme, G7827460458, Protektívny účinok NO a CO donorov pri experimentálnom infarkte myokardu s hypertenzívnymi komplikáciami., G8825872889, G914358866
OpenAlex ID: W2912458249