Work

Coping with chemoresistance in prostate cancer—co-targeting of adipose stromal cells?

Year: 2019

Type: editorial

Abstract: “Obesity begets cancer” is an apt adage considering increasing research pointing to obesity as an important causal factor for increased risk and aggressiveness of many cancer types (1-3). In prostate cancer (PCa), obesity plays a complex role with obesity reported to reduce the risk of localized, low grade, indolent PCa (4) while increasing the risk of aggressive, high grade disease (5). Obesity has been associated with increased PCa mortality as a result of aggressive disease (1,3). In addition, obesity leads to increased risk of biochemical recurrence (BCR) after radical prostatectomy (RP) (4). Considering the increasing prevalence of obesity across populations and increasing incidences and mortality of aggressive PCa, understanding the underlying mechanisms are vital and is currently an area of active investigations.

Source: Translational Andrology and Urology

DOI: 10.21037/tau.2019.01.03

Authors: Divya Bhagirath, Sharanjot Saini

Institutions: San Francisco VA Medical Center, University of California, San Francisco

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: U.S. Department of Defense, National Institutes of Health, DOD Prostate Cancer Research Program