Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion
Year: 2019
Type: article
Abstract: Availability of organs is a limiting factor for lung transplantation, leading to substantial mortality rates on the wait list. Use of organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), would increase organ donation, but these organs are generally not offered for transplantation due to a high risk of transmission. Here, we develop a method for treatment of HCV-infected human donor lungs that prevents HCV transmission. Physical viral clearance in combination with germicidal light-based therapies during normothermic ex-vivo Lung Perfusion (EVLP), a method for assessment and treatment of injured donor lungs, inactivates HCV virus in a short period of time. Such treatment is shown to be safe using a large animal EVLP-to-lung transplantation model. This strategy of treating viral infection in a donor organ during preservation could significantly increase the availability of organs for transplantation and encourages further clinical development.
Source: Nature Communications
Authors: Marcos Galasso, Jordan J. Feld, Yui Watanabe, Mauricio Pipkin, Cara Summers, Aadil Ali, Robert Qaqish, Manyin Chen, Rafaela V. P. Ribeiro, Khaled Ramadan, Layla Pires, Vanderlei S. Bagnato, Cristina Kurachi, Vera Cherepanov, Gray Moonen, Anajara Gazzalle, Thomas K. Waddell, Mingyao Liu, Shaf Keshavjee, Brian C. Wilson, Atul Humar, Marcelo Cypel
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,200
Awards: G1349999890, G1455833180, G2772168918, G3115084672, G3572101131, G3728766230, G402038981, G4773289129, G4843938432, G492292333, G5045443197, G5081325772, National Institute in Basic Optics and Applied to Life Sciences, G6502004700, G7539200513, G794827384, CEPOF - Optics and Photonic Research Center, G8966009742
OpenAlex ID: W2913603052