Work

Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

Year: 2019

Type: article

Abstract: In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.

Source: Biomaterials Science

DOI: 10.1039/c8bm01466c

Authors: R. Fraioli, S. Neubauer, F. Rechenmacher, B. M. Bosch, K. Dashnyam, J.-H. Kim, R. A. Perez, H.-W. Kim, F. J. Gil, M. P. Ginebra, J. M. Manero, H. Kessler, C. Mas-Moruno

Institutions: Universitat Politècnica de Catalunya, Institute for Advanced Study, Technical University of Munich, Universitat Internacional de Catalunya, University College London, Dankook University, Institute for Bioengineering of Catalonia

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Generalitat de Catalunya, Ministerio de Economía y Competitividad, FP7 People: Marie-Curie Actions

Awards: G2869913370, G2888609846, G3909296317, G518860125, G8352252485

OpenAlex ID: W2913777652

FWCI: 0.939

Cites: 36

Cited by: 20

Related to: 10