Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data
Year: 2019
Type: article
Study design: Observational Study
Source: Human Genetics
Authors: Karen Y. He, Xiaoyin Li, Tanika N. Kelly, Jingjing Liang, Brian E. Cade, Themistocles L. Assimes, Lewis C. Becker, Amber L. Beitelshees, Adam P. Bress, Yen-Pei Christy Chang, Yii-Der Ida Chen, Paul S. de Vries, Ervin R. Fox, Nora Franceschini, Anna Furniss, Yan Gao, Xiuqing Guo, Jeffrey Haessler, Shih-Jen Hwang, Marguerite Ryan Irvin, Rita R. Kalyani, Ching-Ti Liu, Chunyu Liu, Lisa Warsinger Martin, May E. Montasser, Paul M. Muntner, Stanford Mwasongwe, Walter Palmas, Alex P. Reiner, Daichi Shimbo, Jennifer A. Smith, Beverly M. Snively, Lisa R. Yanek, Eric Boerwinkle, Adolfo Correa, L. Adrienne Cupples, Jiang He, Sharon L. R. Kardia, Charles Kooperberg, Rasika A. Mathias, Braxton D. Mitchell, Bruce M. Psaty, Ramachandran S. Vasan, D. C. Rao, Stephen S. Rich, Jerome I. Rotter, James G. Wilson, Aravinda Chakravarti, Alanna C. Morrison, Daniel Levy, Donna K. Arnett, Susan Redline, Xiaofeng Zhu
Institutions: Case Western Reserve University, Tulane University, Brigham and Women's Hospital, Harvard University, Stanford University, Johns Hopkins University, Johns Hopkins Medicine, University of Maryland, Baltimore, University of Utah, The Lundquist Institute, Harbor–UCLA Medical Center, The University of Texas Health Science Center at Houston, University of Mississippi Medical Center, University of North Carolina at Chapel Hill, Fred Hutch Cancer Center, Boston University, Framingham Heart Study, University of Alabama at Birmingham, George Washington University, Jackson State University, Columbia University Irving Medical Center, University of Washington, University of Michigan, Wake Forest University Health Sciences, Wake Forest University, Baylor College of Medicine, United States Department of Veterans Affairs, Baltimore VA Medical Center, Kaiser Permanente Washington Health Research Institute, Washington University in St. Louis, University of Virginia, NYU Langone Health, New York University, National Institutes of Health, National Heart, Lung, and Blood Institute, University of Kentucky, Beth Israel Deaconess Medical Center
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: MESA, Genetic Epidemiology of Blood Pressure Intervention, Leveraging Family Data to Identify Genetic Variants for Sleep Apnea, G1409423729, ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPS, Genome-Wide Association of Platelet Phenotypes, G1686417863, Wake Forest Clinical and Translational Science Award, GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS, Coronary Disease Detection by Thalluim SPECT and Fast CT, Large Scale Sequencing and Analysis of Genomes, Rare variants and NHLBI traits in deeply phenotyped cohorts, G2262782284, G232264632, MESA, G2530187302, Longevity Genes in Founder Populations, Identification and Functional characterization of a gene influencing LDL-C on 5q, Genetics of kidney disease in diverse populations, MESA, Genetic & Functional Analyses of Hypertension Susceptibility Genes, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G2971782457, A Family-based Exome Sequencing Approach to Identify Platelet Aggregation Genes, Phenotypic and Molecular Signatures for Sleep Apnea and Related Morbidities, Genomic Predictors of Arteriosclerosis in Hypertensives, G3647016462, Statistical methods for analyzing high-throughput genotype and sequencing data, G3687594596, MESA, General Clinical Research Center, G399481048, Genetic Mechanisms of Arteriosclerosis in Hypertensive Sibships, G4115846997, Whole Genomic Characterization of Sleep Apnea Traits and Comorbid Disorders, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), Genetic ancestry and antihypertensive medication responses in African Americans, The Human Genome Sequencing Center, G4512137732, Biometric Genetic Analysis of CardiopulmonaryDisease, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA, Genotypic Determinants of Aspirin Response in High Risk Families, G5164707915, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, CAD MECHANISMS IN HIGH RISK FAMILIES--RACIAL DIFFERENCE, G5526202189, GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS, G5787256936, G579045871, G6064213486, G6095866717, Genome-wide Search for CVD Gene-Environment Interactions, Genetic Influences on Coronary Artery Calcification, G6359107525, Institute for Clinical and Translational Research, The Framingham Heart Study, MESA, GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS, G6514094751, G6556565091, Leveraging ancestry to map kidney loci, Family-Based Genome-wide Association Study for Salt-Sensitivity of Blood Pressure, Mid-Atlantic Nutrition Obesity Research Center, GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS, MESA, NHLBI FAMILY BLOOD PRESSURE PROGRAM (GENOA), Clinical and Translational Science Award, Studies of Rare Genetic Variation in the Isolated Population of Sardinia, HyperGEN: Genetics of Left Ventricular Hypertrophy, Sodium Sensitivity and Risk of Hypertension, The Family Blood Pressure Program (GENOA Network), G8972711135, Mississippi Center of Excellence in Perinatal Research, Phase 2, Interdisciplinary Training Program in Metabolism, Statistical Analysis of Large Genomic Data Sets, Diabetes Research Center (DRC), IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL, Mississippi Center for Clinical and Translational Research, From GWAS loci to blood pressure genes, variants & mechanisms - Renewal, UAB Diabetes Research Center, UCLA Clinical and Translational Science Institute, G918291509
OpenAlex ID: W2913822366