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A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System

Year: 2019
Type: article
Abstract: Central nervous system (CNS) diseases are the leading cause of morbidity and mortality; their treatment, however, remains constrained by the blood-brain barrier (BBB) that impedes the access of most therapeutics to the brain. A CNS delivery platform for protein therapeutics, which is achieved by encapsulating the proteins within nanocapsules that contain choline and acetylcholine analogues, is reported herein. Mediated by nicotinic acetylcholine receptors and choline transporters, such nanocapsules can effectively penetrate the BBB and deliver the therapeutics to the CNS, as demonstrated in mice and non-human primates. This universal platform, in general, enables the delivery of any protein therapeutics of interest to the brain, opening a new avenue for the treatment of CNS diseases.
DOI: 10.1002/adma.201807557
Authors: Di Wu, Meng Qin, Duo Xu, Lan Wang, Chaoyong Liu, Jie Ren, George Zhou, Chen Chen, Fengmei Yang, Yanyan Li, Yuan Zhao, Ruyi Huang, Sina Pourtaheri, Chunsheng Kang, Masakazu Kamata, Irvin S. Y. Chen, Zhanlong He, Jing Wen, Wei Chen, Yunfeng Lu
Institutions: University of California, Los Angeles, Beijing University of Chemical Technology, Chinese Academy of Medical Sciences & Peking Union Medical College, University of California San Diego, Tianjin Medical University General Hospital, Tianjin Medical University
Language: English
Subfield: Neurology
Open Access status: green
Awards: G1336656697, G1633478156, Nanodelivery platform for antibody drugs targeting NHL, Anti-HIV Gene Therapy: Defend and Attack, G5829405346, Gene engineering using CRISPR/Cas9 mutagenesis to eliminate latent HIV-1, UCLA Center for AIDS Research (CFAR), G7948470807, Gene-Engineered Stem Cell Memory T-Cells With Anti-HIV Chimeric Antigen Receptors, G8716318118, Cancer Center Support Grant
OpenAlex ID: W2916064458
FWCI: 7.417
Cites: 36
Cited by: 145
Related to: 10