Work

Original Antigenic Sin Shapes the Immunological Repertoire Evoked by Human Cytomegalovirus Glycoprotein B/MF59 Vaccine in Seropositive Recipients

Year: 2019

Type: article

Abstract: A human cytomegalovirus (HCMV) vaccine is urgently needed to protect against primary infection and enhance existing immunity in HCMV-infected individuals (HCMV+). Using sera from HCMV+ glycoprotein B/MF59 vaccine recipients prior to transplant, we investigated the composition of the immune response. Vaccination boosted preexisting humoral responses in our HCMV+ cohort but did not promote de novo responses against novel linear epitopes. This suggests that prior natural infection has a profound effect on shaping the antibody repertoire and subsequent response to vaccination ("original antigenic sin"). Thus, vaccination of HCMV+ may require strategies of epitope presentation distinct from those intended to prevent primary infection.

Source: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jiz089

Authors: Ilona Baraniak, Florian Kern, Pavlo Holenya, Paul Griffiths, Matthew Reeves

Institutions: University College London, Brighton and Sussex Medical School, JPT Peptide Technologies (Germany)

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Rosetrees Trust, Sanofi Pasteur, National Institute of Allergy and Infectious Diseases, Royal Free Charity