Work

Assessment of Pain Associated with the Injection of Sodium Pentobarbital in Laboratory Mice (Mus musculus)

Year: 2019

Type: article

Abstract: = 84). The number of responders, latency until the first lick, and the number of licks per responder were recorded. The number of responders was increased in the 50-mg/mL group; however, there was no difference in latency or the number of licks per responder. These results show that intraperitoneal injection of sodium pentobarbital for euthanasia in mice did not result in increased behavioral signs of pain, and animals lose consciousness more rapidly than the onset of pain seen in the pawlick test. Therefore, although sodium pentobarbital is capable of inducing inflammation, euthanasia through intraperitoneal administration is rapid and does not result in overt signs of pain when compared with injection of saline.

Source: Journal of the American Association for Laboratory Animal Science

DOI: 10.30802/aalas-jaalas-18-000094

Authors: John W Dutton, James E Artwohl, Xichen Huang, Jeffrey D Fortman

Institutions: Texas Biomedical Research Institute, University of Illinois Chicago, University of Illinois Urbana-Champaign

Language: English

Topic: Veterinary Pharmacology and Anesthesia

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, University of Illinois at Urbana-Champaign, University of Illinois at Chicago