Effect of Clonidine versus magnesium sulphate on hemodynamic response to laryngoscopy in day care surgeries: A prospective, randomized, single-center study
Year: 2019
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background: Prevention of hemodynamic response to laryngoscopy and intubation is always an integral component of a balanced anesthesia technique and has an escalated significance in the era of day care surgeries.Researchers have always struggled to arrive at a consensus on an ideal drug and its dose to control the laryngoscopy response.As such a drug with more physiological pharmacodynamic profile, magnesium sulfate, can be advantageous in majority of cases.We compare it with another potent drug, clonidine, an alpha2 agonist, which has proven its role in attenuating laryngoscopic response in earlier studies.Methods: A single-centre prospective randomized double-blinded study was conducted on 90 patients with ASA grade 1 and 2 undergoing elective laparoscopic cholecystectomy using general anaesthesia.Patients were randomly assigned to receive either MgSO4 (elemental Magnesium 50mg/kg), clonidine 2 micrograms/kg or normal saline (NS) prior to induction and evaluated for hemodynamic responses to laryngoscopy.Data was compared using Oneway ANOVA, Kruskal-Wallis and Chi-Square tests.Results: Clonidine group was better than magnesium sulphate group in attenuating the rise in heart rate associated with laryngoscopy while magnesium sulphate and clonidine were equally effective in controlling the rise in blood pressure associated with laryngoscopy.Conclusion: Both IV Magnesium sulphate 50mg/kg and IV Clonidine 2mcg/kg given prior to the induction of anesthesia in laparoscopic surgery effectively attenuated the hemodynamic response to laryngoscopy with Clonidine being better than magnesium sulphate in controlling the rise heart rate associated with laryngoscopy.
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2925252136