Work

Toxoplasma gondiiModulates the Host Cell Responses: An Overview of Apoptosis Pathways

Year: 2019

Type: review

Abstract: Infection withToxoplasma gondiihas a major implication in public health.Toxoplasma gondiiis an obligate intracellular protozoan parasite that can infect all nucleated cells belonging to a wide range of host species. One of the particularities of this parasite is its invasion and persistence in host cells of immunocompetent people. This infection is usually asymptomatic. In immunocompromised patients, the infection is severe and symptomatic. The mechanisms by whichT. gondiipersists are poorly studied in humans. In mouse models, many aspects of the interaction between the parasite and the host cells are being studied. Apoptosis is one of these mechanisms that could be modulated byToxoplasmato persist in host cells. Indeed,Toxoplasmahas often been implicated in the regulation of apoptosis and viability mechanisms in both human and murine infection models. Several of these studies centered on the regulation of apoptosis pathways have revealed interference of this parasite with host cell immunity, cell signalling, and invasion mechanisms. This review provides an overview of recent studies concerning the effect ofToxoplasmaon different apoptotic pathways in infected host cells.

Source: BioMed Research International

DOI: 10.1155/2019/6152489

Authors: Nour Mammari, Mohamad Adnan Halabi, Souha Yaacoub, Hilda Chlala, Marie-Laure Dardé, Bertrand Courtioux