Work

The Study of the Transgeneration Genotoxic Effect of Drugs Based on the Analysis of Synaptonemal Complexes in Mouse Spermatocytes

Year: 2018

Type: conference-paper

Abstract: The research employs immmunocytochemical methods to study the synaptonemal complexes (SC), and it targets the primary spermatocytes of mice from the offspring of males who received antimicrobialsThe males in the offspring of fathers received bacteriophage, nitrofural and cifran.When comparing the total number of damaged cells, they did not show a significant difference with the control animals.However, when comparing the spectrum of affects, they presented a significantly increased number of cells having ring SC-bivalents in the offspring of males treated with cifran.This may indicate an increase in chromosome fragility, leading to the deletion of telomere regions of chromosomes, which in turn causes the formation of ring bivalents.

Source: Proceedings of the International Symposium “Engineering and Earth Sciences: Applied and Fundamental Research” (ISEES 2018)

DOI: 10.2991/isees-18.2018.27

Authors: Maret M. Atsayeva, Zura I. Bisultanova, Petimat M. Dzhambetova, Nadezhda Yu. Oyun, Oksana L. Kolomiets