Year: 2019
Type: article
Abstract: Tungsten oxide sol, containing highly crystalline nanoparticles of orthorhombic WO3 and having good sedimentation stability, was synthesized using a facile, ultrasonic-assisted technique. An additional steric stabilizer, dextran, was proposed to enhance the stability of WO3 nanoparticles in biological media and to reduce their in vivo toxicity. The cytotoxicity of dextran-stabilized and nonstabilized WO3 sols was studied in vitro using dental pulp stem (DPS) cell lines and breast cancer (MCF-7) cell lines. Both tungsten oxide sols demonstrated low cytotoxicity and low genotoxicity for both stem cells and malignant cells and only slightly reduced their metabolic activity in the concentration range studied (from 0.2 to 200 μg/ml). The data obtained support possible theranostic applications of tungsten oxide colloidal solutions.
Source: Journal of Nanomaterials
DOI: 10.1155/2019/5384132
Authors: B. Han, A. L. Popov, T. O. Shekunova, D. A. Kozlov, O. S. Ivanova, A. A. Rumyantsev, A. B. Shcherbakov, N. R. Popova, A. E. Baranchikov, V. K. Ivanov
Institutions: Jiangsu University of Technology, Russian Academy of Sciences, Institute of Theoretical and Experimental Biophysics, Lomonosov Moscow State University, NS Kurnakova Institute of General and Inorganic Chemistry, National Academy of Sciences of Ukraine, Danylo Zabolotny Institute of Microbiology and Virology, National Research Tomsk State University
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $2,375
Funder: Russian Science Foundation
Award: G1291505364
OpenAlex ID: W2942498844