Work

Resolution of an Atropisomeric Naphthamide by Second-Order Asymmetric Transformation: A Highly Productive Technique

Year: 2019

Type: article

Abstract: Temperature-cycle-induced deracemization (TCID) has been widely studied in the field of chiral separation, ranging from fundamental research to applications. In this study, the second-order asymmetric transformation (SOAT) of 2-methoxy-1-naphthamide in an azeotropic mixture of ethyl acetate and cyclohexane is compared with TCID, in terms of process productivity. The results indicate that the volumetric productivity using SOAT was over 100-times higher than that using TCID, such that a scale-up by a factor of 10 was easily implemented.

Source: Organic Process Research & Development

DOI: 10.1021/acs.oprd.9b00133

Authors: Ryusei Oketani, Marine Hoquante, Clément Brandel, Pascal Cardinael, Gérard Coquerel

Institutions: Laboratoire Sciences et Méthodes Séparatives, Université de Rouen Normandie

Language: English

Topic: Analytical Chemistry and Chromatography

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: H2020 Marie Skłodowska-Curie Actions

OpenAlex ID: W2945192607

FWCI: 2.16

Cites: 48

Cited by: 34

Related to: 10