Year: 2018
Type: article
Study design: Observational Study
Abstract: Background: Gastric adenocarcinoma is a serious and frequent digestive cancer.It is the second leading cause of cancer deaths in the world after colorectal cancer.The bad prognosis is caused by several factors.The identification of prognostic factors will make it possible to better codify therapeutic management in order to improve survival and reduce recurrence rates.Aim: Identify the main prognostic factors affecting overall survival and recurrence in gastric adenocarcinoma.Methods: Retrospective study involving patients undergoing surgery for gastric adenocarcinoma between January 2006 and March 2016 in Habib Bougatfa Hospital in Tunisia.Results: Overall survival was 58% at 3 years.Survival without recurrence was 20 months.Survival without recurrence at 1 year, 3 years and 5 years were respectively 88%, 73% and 70%.Eleven patients had a recurrence.The median time to onset of recurrence was 12 months.Of the 11 patients who had a recurrence, nine had died.Mortality due to recurrence was 82%.In univariate analysis, overall survival and recurrence were influenced by several factors.After multivariate analysis, lymph node invasion, occurrence of recurrence, number of lymph nodes removed less than 15, presence of signet-ring cell carcinoma and tumor stage 3 and 4 significantly influenced survival.Independent factors influenced recurrences were: the presence of lymph nodes and signet ring cell carcinoma.Conclusion: Several factors influence overall survival and recurrence in gastric adenocarcinoma.The lymph node invasion and the anatomo-pathological factors are the most important.Improving therapeutic outcomes requires early diagnosis and careful surgery.
Source: Cancer Reports and Reviews
DOI: 10.15761/crr.1000171
Institution: Tunis El Manar University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2946036719